Investigation of antibiotic release from amoxicillin- and clindamycin-impregnated silk and Vicryl suture materials: an in vitro study

Surface modification with atmospheric plasma is an effective strategy to enhance the functional characteristics of antibiotic-releasing sutures. This study demonstrates that modified silk and Vicryl materials can achieve site-specific and time-regulated antibiotic delivery. Notably, the silk-glutaraldehyde-clindamycin formulation exhibited the highest release levels and the most robust antibacterial response. These findings suggest that antibiotic-loaded sutures serve as a safe and practical alternative for preventing surgical site infections, potentially reducing reliance on systemic antibiotics. Ultimately, this approach supports the development of next-generation biomaterials designed to mitigate antibiotic resistance and optimize local infection control.