Of Barriers and Loops—How Evolution Limits Most Cancer Risks to Older Ages

Better understanding of the multiple barriers that we have evolved to limit cancer development and how they can fail at older ages could enable the development of preventative and therapeutic interventions that boost these tumor-suppressive mechanisms.

Authors

Marco De Dominici (ORCID: https://orcid.org/0000-0002-1019-1715)
James V. DeGregori (ORCID: https://orcid.org/0000-0002-1287-1976)

Institutions

University of Colorado Anschutz Medical Campus (US)

Publication Details

Journal: Cancer Discovery
Published: 2026-01-12
DOI: https://doi.org/10.1158/2159-8290.cd-25-0779
Primary Topic: Cancer Genomics and Diagnostics
Type: article
Field-Weighted Citation Impact: 0.00

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article

Of Barriers and Loops—How Evolution Limits Most Cancer Risks to Older Ages

Marco De Dominici, James V. DeGregori

Jan 12, 2026

Cancer Discovery

Cancer Genomics and Diagnostics

article

Of Barriers and Loops—How Evolution Limits Most Cancer Risks to Older Ages

Marco De Dominici, James V. DeGregori

January 12, 2026article en

Abstract

Cancer DiscoveryVol. 16(1)

University of Colorado Anschutz Medical Campus (US)

Openalex Percentile: Top 90%

Cancer Genomics and Diagnostics

DOI Open Access PDF OpenAlex

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Of Barriers and Loops—How Evolution Limits Most Cancer Risks to Older Ages — Marco De Dominici, James V. DeGregori · Cancer Discovery (2026) | TGRS Research Map | TGRS