Tunable dual-AAV sparse labeling of PV+ retinal ganglion cells enables single-neuron projection by fMOST
This viral labeling platform effectively resolves the classical trade-off between sparsity and signal intensity, providing a robust methodology for whole-brain mapping of individual RGC projections. The approach establishes a practical foundation for future mechanistic and therapeutic studies investigating subtype-selective vulnerability in RGCs.
Authors
- Min Yuan (ORCID: https://orcid.org/0009-0002-3305-4294)
- Shen Yp
- Wenxiao Zhang (ORCID: https://orcid.org/0000-0001-7052-5011)
- Lingbo Zhou
- Li Yu
- Gao Tan
- Qitian Wang
- Sen Jin
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
- Io Therapeutics (United States) (US)
Publication Details
- Journal
- Frontiers in Neural Circuits
- Published
- 2026-01-12
- DOI
- https://doi.org/10.3389/fncir.2025.1740624
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China