Spontaneous somatic Pten loss contributes to functional heterogeneity of T cells
We found that healthy mice harbor T cells with heritable low Pten expression and that monoallelic Pten loss in CD4 T cells causes a bias in their differentiation toward T follicular helper cells during acute viral infection. These results suggest that somatically induced mono- or biallelic loss of expression of signaling-related genes in T cells can impact the quality of population-level T cell responses-without conspicuous pathological sequelae such as autoimmune and inflammatory manifestations or lymphomagenesis.
Authors
- Allen Y. Chen
- Alexander Y. Rudensky (ORCID: https://orcid.org/0000-0003-1280-2898)
Institutions
- Hospital for Special Surgery (US)
- Memorial Sloan Kettering Cancer Center (US)
- Kettering University (US)
- New York University (US)
Publication Details
- Journal
- Scientific Reports
- Published
- 2026-01-12
- DOI
- https://doi.org/10.1038/s41598-025-34754-1
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Memorial Sloan-Kettering Cancer Center
- Hospital for Special Surgery
- Cycle for Survival
- York University
- National Institutes of Health
- School of Medicine, New York University
- Ludwig Center at Harvard
- Marie-Josée and Henry R. Kravis Center for Molecular Oncology
- National Cancer Institute