Bromo- and chloro-substituted flavones induce apoptosis and modulate cell death pathways in canine lymphoma and leukemia cells - a comparative in vitro study
Halogenated flavones display distinct cytotoxic profiles in canine B-cell leukemia and lymphoma models, with BrCl-F showing the highest anticancer activity. These findings support further investigation of halogenated flavones as potential anticancer agents in comparative oncology.
Authors
- Edyta Kostrzewa-Susłow (ORCID: https://orcid.org/0000-0002-9259-0161)
- Ewa Dejnaka (ORCID: https://orcid.org/0009-0007-9509-4845)
- Aleksandra Pawlak (ORCID: https://orcid.org/0000-0002-7449-1661)
- Hanna Pruchnik (ORCID: https://orcid.org/0000-0001-5229-4299)
- Agnieszka Krawczyk-Łebek (ORCID: https://orcid.org/0000-0002-9507-0196)
- Joanna Sulecka-Zadka
- Anita Dudek
- Martyna Perz
Institutions
- University of Life Sciences in Lublin (PL)
- University of Georgia (US)
- Medical University of Warsaw (PL)
- Wrocław University of Environmental and Life Sciences (PL)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2026-01-12
- DOI
- https://doi.org/10.3389/fmolb.2025.1738255
- Citations
- 1
- Primary Topic
- Bioactive Compounds in Plants
- Type
- article
- Field-Weighted Citation Impact
- 31.34
Funders
- Uniwersytet Przyrodniczy we Wrocławiu