Integrated multi-omic profiling reveals macrophage-driven prognostic signatures in clear cell renal cell carcinoma through machine learning optimization

This multi-omics study illuminates the transcriptional and functional heterogeneity of TAMs in KIRC and establishes a macrophage-derived prognostic signature with translational potential. Our findings underscore the dual roles of macrophage polarization in mediating immune suppression and metabolic adaptation, offering novel targets for clinical diagnosis and treatment of KIRC.