Prognostic value of tumor-informed ctDNA in HPV-independent head and neck squamous cell carcinoma
Tumor-informed ctDNA MRD positivity was associated with worse RFS and OS in patients with HNSCC. MRD testing could serve as a non-invasive, prognostic biomarker in HPV- HNSCC patients.
Authors
- Vasileios Efthymiou (ORCID: https://orcid.org/0000-0001-6139-9535)
- Jonathan J. Paly (ORCID: https://orcid.org/0000-0003-1436-9389)
- Saskia Naegele (ORCID: https://orcid.org/0000-0002-0935-7861)
- Mark A. Varvares (ORCID: https://orcid.org/0000-0002-6570-5672)
- Ross D. Merkin (ORCID: https://orcid.org/0000-0003-3418-2220)
- Allen L. Feng (ORCID: https://orcid.org/0000-0002-8040-5299)
- Giancarlo Bonora (ORCID: https://orcid.org/0000-0001-7558-3798)
- Daniel A. Ruiz Torres
- Julia Mendel
- Adam Fisch
- S. Jia
- Daniel G Deschler
- Frank Zhang
- Thomas J Roberts
- Pan Du
- Daniel L Faden
- Derrick T Lin
Institutions
- Broad Institute (US)
- Massachusetts Eye and Ear Infirmary (US)
- Harvard University (US)
- Massachusetts General Hospital (US)
- Advanced Cell Diagnostics (United States) (US)
- Center for Cancer Research (US)
Publication Details
- Journal
- medRxiv
- Published
- 2026-01-12
- DOI
- https://doi.org/10.64898/2026.01.09.26343802
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute of Dental and Craniofacial Research