Impact of Maternal Diabetes in Pregnancy on Newborn IgG Antibody Repertoire and Infection Risk in the First 6 Months of Life
This study provides strong evidence of an increased infection risk in the infants of mothers with diabetes and a reduced IgG repertoire diversity in those of PDM mothers. Lower IgG diversity exacerbated the diabetes-infection link. These findings suggest that maternal metabolic conditions may impact an infant's passive immunity and susceptibility to infections.
Authors
- María J. Gutiérrez (ORCID: https://orcid.org/0000-0001-5494-5841)
- Colleen Pearson (ORCID: https://orcid.org/0000-0001-6669-6774)
- William G. Adams (ORCID: https://orcid.org/0000-0002-5330-0010)
- Xiumei Hong
- Hongkai Ji
- Xiaobin Wang
- H. Benjamin Larman
- Guoying Wang
- Pamela A. Frischmeyer-Guerrerio
Institutions
- Boston Medical Center (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- National Institute of Allergy and Infectious Diseases (US)
Publication Details
- Journal
- Diabetes Care
- Published
- 2026-01-12
- DOI
- https://doi.org/10.2337/dc25-0990
- Primary Topic
- Gestational Diabetes Research and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00