In vitro characterization of hemoglobin oxygen dissociation curves and electrolyte shifts in human blood under varying PCO2
These findings, validated against external datasets, underscore the tight coupling between respiratory gas exchange and electrolyte homeostasis. The study provides novel insights into how CO<sub>2</sub> modulates both oxygen delivery and plasma ionic composition, with implications for understanding acid-base physiology and its regulation in health and disease.
Authors
- Sebastiano Maria Colombo (ORCID: https://orcid.org/0000-0002-9612-5187)
- F. Gori
- Carlo Valsecchi
- E. Carlesso
- Giacomo Grasselli (ORCID: https://orcid.org/0000-0002-1735-1400)
- M. Battistin
- Alberto Zanella (ORCID: https://orcid.org/0000-0003-0807-8761)
- Thomas Langer
Institutions
- University of Milan (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda (IT)
- University of Milano-Bicocca (IT)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-01-12
- DOI
- https://doi.org/10.3389/fmed.2025.1708274
- Primary Topic
- Hemoglobin structure and function
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministero della Salute
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico