Potential molecular pathways and therapeutic implications of rapid-acting antidepressants on myelin biology: a scoping review

Myelin regulation may represent a component of RAAD action, indicating that these agents could influence myelin biology. Further research is required to clarify the mechanisms underlying these effects, their potential implications for therapies aimed at preserving or restoring myelin integrity, and potential side effects. Their dose-dependent effects highlight the need for careful consideration of dosing and treatment duration.

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Publication Details

Journal
Frontiers in Neuroscience
Published
2026-01-12
DOI
https://doi.org/10.3389/fnins.2025.1690318
Primary Topic
Neurogenesis and neuroplasticity mechanisms
Type
article
Field-Weighted Citation Impact
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article

Potential molecular pathways and therapeutic implications of rapid-acting antidepressants on myelin biology: a scoping review

Jared VanderZwaag, Marie‐Ève Tremblay, Colin J. Murray, Antonella Campanale et al.
Frontiers in Neuroscience
Neurogenesis and neuroplasticity mechanisms
article

Potential molecular pathways and therapeutic implications of rapid-acting antidepressants on myelin biology: a scoping review

Jared VanderZwaag, Marie‐Ève Tremblay, Colin J. Murray, Antonella Campanale, Antonio Inserra
article en

Abstract

Myelin regulation may represent a component of RAAD action, indicating that these agents could influence myelin biology. Further research is required to clarify the mechanisms underlying these effects, their potential implications for therapies aimed at preserving or restoring myelin integrity, and potential side effects. Their dose-dependent effects highlight the need for careful consideration of dosing and treatment duration.

Frontiers in NeuroscienceVol. 19
University of Victoria (CA), University of Chieti-Pescara (IT), Universidade do Sul de Santa Catarina (BR), McGill University (CA)
Openalex Percentile: Top 92%
Neurogenesis and neuroplasticity mechanisms
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