Raised alpha fetoprotein in cirrhotic liver with colorectal liver metastasis mimicking hepatocellular carcinoma: case report and review of literature

AFP-producing colorectal adenocarcinoma with liver metastases can masquerade as HCC, particularly in patients with underlying liver disease. This case underscores the need for histological confirmation of atypical hepatic lesions to avoid misdiagnosis. Awareness of this rare entity and careful clinical reasoning are crucial to guide appropriate management and highlight pitfalls in diagnostic practice.

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Publication Details

Journal
Diagnosis
Published
2026-01-12
DOI
https://doi.org/10.1515/dx-2025-0143
Primary Topic
Hepatocellular Carcinoma Treatment and Prognosis
Type
article
Field-Weighted Citation Impact
0.00
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article

Raised alpha fetoprotein in cirrhotic liver with colorectal liver metastasis mimicking hepatocellular carcinoma: case report and review of literature

Samah Mansour, Aboje Adugba, Abdallah Al Farai, Kareem Al Rezk et al.
Diagnosis
Hepatocellular Carcinoma Treatment and Prognosis
article

Raised alpha fetoprotein in cirrhotic liver with colorectal liver metastasis mimicking hepatocellular carcinoma: case report and review of literature

Samah Mansour, Aboje Adugba, Abdallah Al Farai, Kareem Al Rezk, Dominic Obotu Ayegba, Rawan AlMallah
article en

Abstract

AFP-producing colorectal adenocarcinoma with liver metastases can masquerade as HCC, particularly in patients with underlying liver disease. This case underscores the need for histological confirmation of atypical hepatic lesions to avoid misdiagnosis. Awareness of this rare entity and careful clinical reasoning are crucial to guide appropriate management and highlight pitfalls in diagnostic practice.

Diagnosis
Sultan Qaboos University Hospital (OM), Sultan Qaboos University (OM)
Good health and well-being
Openalex Percentile: Top 90%
Hepatocellular Carcinoma Treatment and Prognosis
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