Genetic Determinants for Vivax Malaria Susceptibility in Chiplun (Ratnagiri), Maharashtra, India: A Case–Control Study
Our findings demonstrate significant associations between certain blood group phenotypes and α-globin genotypes with malaria susceptibility in the population from Chiplun. The strong association of homozygous-α<sup>3</sup>·<sup>7</sup> deletion with increased malaria risk contradicts the protective effect reported in some populations, highlighting the complex and potentially region-specific nature of genetic factors influencing malaria susceptibility. These results contribute to understanding the genetic epidemiology of malaria in India and may inform targeted public health interventions in similar endemic regions.
Authors
- Singh Arti
- Gorakshakar Ajit
- Jadhav Jyoti
- Ghosh Kanjaksha
- Shinde Shivam
- Mahadik Kanchan
- Shaikh Roshan
Institutions
- ICMR - National Institute of Immunohaemotology (IN)
- Primary Health Care (QA)
- Research Institute of Health Sciences (ES)
Publication Details
- Journal
- Tropical Medicine & International Health
- Published
- 2026-01-12
- DOI
- https://doi.org/10.1111/tmi.70083
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00