The rare report of unicentric Castleman disease with concurrent myasthenia gravis and paraneoplastic pemphigus: a case report with a focused review of the literature

This case highlights a rare and diagnostically challenging overlap of CD, MG, and PNP. Accurate recognition required integration of histopathology, immunofluorescence, and serological testing, achieved through multidisciplinary collaboration across thoracic surgery, neurology, dermatology, and pathology. Clinicians should remain vigilant for such complex presentations, as early diagnosis and coordinated management are essential to improving outcomes in rare autoimmune-associated CD.

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Publication Details

Journal
Frontiers in Oncology
Published
2026-01-12
DOI
https://doi.org/10.3389/fonc.2025.1717172
Primary Topic
Viral-associated cancers and disorders
Type
article
Field-Weighted Citation Impact
0.00
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article

The rare report of unicentric Castleman disease with concurrent myasthenia gravis and paraneoplastic pemphigus: a case report with a focused review of the literature

Wenliang Liu, Zeyu Cheng, Yan Hu
Frontiers in Oncology
Viral-associated cancers and disorders
article

The rare report of unicentric Castleman disease with concurrent myasthenia gravis and paraneoplastic pemphigus: a case report with a focused review of the literature

Wenliang Liu, Zeyu Cheng, Yan Hu
article en

Abstract

This case highlights a rare and diagnostically challenging overlap of CD, MG, and PNP. Accurate recognition required integration of histopathology, immunofluorescence, and serological testing, achieved through multidisciplinary collaboration across thoracic surgery, neurology, dermatology, and pathology. Clinicians should remain vigilant for such complex presentations, as early diagnosis and coordinated management are essential to improving outcomes in rare autoimmune-associated CD.

Frontiers in OncologyVol. 15
Central South University (CN), Second Xiangya Hospital of Central South University (CN)
Openalex Percentile: Top 90%
Viral-associated cancers and disorders
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