Homeometric autoregulation in severe aortic stenosis: insights from transcatheter aortic valve replacement
Contractility declined in the near-term postoperative period following TAVR. We interpret this finding to suggest that contractility is augmented by high afterload in severe AS and declines in parallel with afterload reduction. We speculate that autoregulatory mechanisms triggered by high valvular resistance support LVEF in severe AS and rapidly abate following TAVR.
Authors
- Adam Doerr (ORCID: https://orcid.org/0009-0006-4611-7919)
- Nikolaos Kakouros (ORCID: https://orcid.org/0000-0002-2289-7598)
- Matthew Gottbrecht (ORCID: https://orcid.org/0000-0001-5245-9356)
- Colleen Harrington (ORCID: https://orcid.org/0000-0002-2830-9953)
- Matthew W. Parker (ORCID: https://orcid.org/0000-0002-3772-3742)
- Gerard P. Aurigemma
Institutions
- UMass Memorial Health Care (US)
- Harvard University (US)
- University of Massachusetts Chan Medical School (US)
- Saint Vincent Hospital (US)
- UMass Memorial Medical Center (US)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2026-01-12
- DOI
- https://doi.org/10.3389/fcvm.2025.1677372
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00