Rod-Cone Dystrophy Related WDR34 Is Essential for Ciliary Integrity and Survival of Mammalian Photoreceptor Cells
Our findings establish WDR34 as a critical factor for photoreceptor survival and function, emphasizing its role in the pathogenesis of WDR34-associated retinal degeneration. Moreover, this study demonstrates that WDR34-targeted gene therapy can effectively delay photoreceptor loss, highlighting a promising treatment strategy for patients with WDR34-related retinal disease.
Authors
- C. H. Chen
- Fan Lin (ORCID: https://orcid.org/0000-0001-9169-9416)
- Jinrui Cai
- Xian Yang
- Luning Liu
- Guangyi Chen
- Xianjun Zhu
- Rong Zou
- Kuanxiang Sun
Institutions
- Qingdao University (CN)
- Chongqing University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-01-12
- DOI
- https://doi.org/10.1167/iovs.67.1.26
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Department of Science and Technology of Sichuan Province