In synergy with interferon‐gamma, interleukin‐17 activates vascular stromal cells towards a pro‐inflammatory profile in giant cell arteritis
IL-17 exacerbates vascular inflammation in GCA by activating MFs and synergizing with IFN-γ to increase production of pro-inflammatory cytokines (IL-6, GM-CSF), chemokines (CCL20, CCL2), and angiogenic factors (VEGF, indicating that IL-17 is a key contributor to disease pathogenesis.
Authors
- Corentin Richard (ORCID: https://orcid.org/0000-0001-9732-0219)
- S. Audia
- Bernard Bonnotte
- Hélène Greigert
- Roman Praliaud
- Louis Arnould (ORCID: https://orcid.org/0000-0001-7831-8818)
- Romain Boidot (ORCID: https://orcid.org/0000-0001-9956-1737)
- M. Ciudad
- Baptiste Lamarthée (ORCID: https://orcid.org/0000-0002-8417-1661)
- Georges Tarris (ORCID: https://orcid.org/0000-0002-2901-6618)
- G. Brenac (ORCID: https://orcid.org/0009-0005-9828-1529)
- Noémie Herrmann
- Alexis Varin
- André Ramon
- Catherine P. Creuzot‐Garcher
- Jérôme Razanamahery (ORCID: https://orcid.org/0000-0001-8453-7224)
- Pierre‐Henry Gabrielle
- Claudie Cladiere
- Laurent Martin
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université de Bourgogne (FR)
- Centre Georges François Leclerc (FR)
- Maison des Sciences sociales et des Humanités de Dijon (FR)
- Université Marie et Louis Pasteur (FR)
- Université de Franche-Comté (FR)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2026-01-12
- DOI
- https://doi.org/10.1002/art.70051
- Primary Topic
- Vasculitis and related conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00