FACS-based genome-wide CRISPR screening platform identifies modulators of CD47
Overall, this study highlights a previously unrecognized regulator of CD47 and demonstrates the utility of high-throughput FACS-based CRISPR screening to uncover modulators of key immune checkpoint pathways.
Authors
- Francisco Sáenz (ORCID: https://orcid.org/0000-0003-4738-4710)
- Yifan Wang (ORCID: https://orcid.org/0000-0001-7056-6251)
- J. Zhang
- S B Li
- Jialing Fu (ORCID: https://orcid.org/0009-0001-5970-3486)
- Min Huang (ORCID: https://orcid.org/0000-0003-1504-4754)
- Jun Chen (ORCID: https://orcid.org/0000-0001-8051-5503)
- Ling Yin (ORCID: https://orcid.org/0009-0009-0526-6303)
- Chang Yang
- Dandan Zhu
- Wei He
- Xu Feng
- Yuelong Yan
Institutions
- The University of Texas MD Anderson Cancer Center (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-12
- DOI
- https://doi.org/10.3389/fimmu.2025.1684539
- Citations
- 1
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 24.43
Funders
- National Institutes of Health
- National Cancer Institute