Spurious test results as a diagnostic clue – pseudohyponatremia revealing multiple myeloma

This case highlights the importance of artifacts in laboratory measurement, in this case recognizing analytical interferences when discordant hyponatremia is found. Confirmatory testing by direct potentiometry ion-specific electrodes prevents misdiagnosis and inappropriate therapy. Early identification of pseudohyponatremia further emphasizes the crucial role of the laboratory in ensuring accurate interpretation and optimizing patient management.

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Publication Details

Journal
Diagnosis
Published
2026-01-12
DOI
https://doi.org/10.1515/dx-2025-0150
Primary Topic
Electrolyte and hormonal disorders
Type
article
Field-Weighted Citation Impact
0.00
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article

Spurious test results as a diagnostic clue – pseudohyponatremia revealing multiple myeloma

Macarena Calvente de Rávena, María Ortiz-Espejo, F. Pons-Vidal
Diagnosis
Electrolyte and hormonal disorders
article

Spurious test results as a diagnostic clue – pseudohyponatremia revealing multiple myeloma

Macarena Calvente de Rávena, María Ortiz-Espejo, F. Pons-Vidal
article en

Abstract

This case highlights the importance of artifacts in laboratory measurement, in this case recognizing analytical interferences when discordant hyponatremia is found. Confirmatory testing by direct potentiometry ion-specific electrodes prevents misdiagnosis and inappropriate therapy. Early identification of pseudohyponatremia further emphasizes the crucial role of the laboratory in ensuring accurate interpretation and optimizing patient management.

Diagnosis
Marqués de Valdecilla University Hospital (ES), Sociedad Española de Medicina de Familia y Comunitaria (ES)
Openalex Percentile: Top 91%
Electrolyte and hormonal disorders
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