Simultaneous Determination of Venetoclax and Posaconazole in Human Plasma by UPLC-MS/MS: Application to Therapeutic Drug Monitoring in Acute Myeloid Leukemia Patients
A rapid and simple method was established and successfully applied to the simultaneous determination of the concentrations of venetoclax and posaconazole in AML patients, providing a basis for TDM and clinical pharmacokinetic analysis of these drugs in AML patients.
Authors
- Haoxin Fu
- Lu Cao (ORCID: https://orcid.org/0000-0001-6644-0963)
- Xiaohai Chen (ORCID: https://orcid.org/0009-0009-5017-5515)
- Ruanjuan Zhan
- Ruibin Li
- Ren-Ai Xu
- Hualu Wu
- Peiqi Wang
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2026-01-01
- DOI
- https://doi.org/10.2147/dddt.s537699
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.00