4D-CT strain analysis for biomechanical characterization of COPD in patients undergoing radiotherapy planning: an exploratory study
This exploratory study provides preliminary evidence that 4D-CT strain analysis, particularly Speedmax, shows promise for differentiating normal lung function from COPD in patients with small pulmonary lesions. However, given the small sample size and single-center design, diagnostic performance metrics should be interpreted with caution. External validation in larger, multi-center cohorts is required before clinical implementation.
Authors
- H. Chen
- Xiaoxiao Zhu (ORCID: https://orcid.org/0000-0001-7815-6572)
- Jingyun Shi (ORCID: https://orcid.org/0000-0001-6576-5184)
- X. L. Wang (ORCID: https://orcid.org/0000-0001-5805-1255)
- Qin Dai
- Bin Chen
Institutions
- Tongji University (CN)
- Ningbo No. 2 Hospital (CN)
- Shanghai Pulmonary Hospital (CN)
- Ningbo No.6 Hospital (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-01-12
- DOI
- https://doi.org/10.3389/fmed.2025.1703045
- Primary Topic
- Effects of Radiation Exposure
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Ningbo
- Hwa Mei Hospital, University of Chinese Academy of Sciences
- Natural Science Foundation of Zhejiang Province