Dysregulation of <scp>U12</scp> ‐Type Splicing in Lupus Neutrophils
Impaired U12-dependent splicing may contribute to neutrophil dysfunction in SLE, potentially via defective oxidative burst and altered immune regulation. These findings highlight the minor spliceosome as a novel player in lupus pathogenesis.
Authors
- Mariana J. Kaplan (ORCID: https://orcid.org/0000-0003-2968-0815)
- Luz P. Blanco
- Binod Regmi
- Xuhui Wang (ORCID: https://orcid.org/0000-0003-0818-9816)
- Hongwei Sun (ORCID: https://orcid.org/0000-0001-7645-8593)
- Yudong Liu (ORCID: https://orcid.org/0009-0003-0491-5873)
- Philip M. Carlucci
- Zerai Manna
- Monica M. Jackson
- Carmelo Carmona‐Rivera
- Markus Hafner
Institutions
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (US)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2026-01-12
- DOI
- https://doi.org/10.1002/art.70053
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00