Combining Thyroid Imaging Report and Data System (TIRADS) and Afirma Genomic Sequencing Classifier (GSC) for potential improvement of malignant risk stratification of Bethesda III thyroid nodules

A GSC-suspicious result combined with TIRADS 5 significantly improved the positive predictive value, thereby enhancing risk stratification in AUS thyroid nodules, while other diagnostic parameters remained unchanged.

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Publication Details

Journal
Journal of the American Society of Cytopathology
Published
2026-01-01
DOI
https://doi.org/10.1016/j.jasc.2026.01.001
Primary Topic
Thyroid Cancer Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Combining Thyroid Imaging Report and Data System (TIRADS) and Afirma Genomic Sequencing Classifier (GSC) for potential improvement of malignant risk stratification of Bethesda III thyroid nodules

Brian Smola, Xin Jing, Xiaobing Jin, Y. Geng et al.
Journal of the American Society of Cytopathology
Thyroid Cancer Diagnosis and Treatment
article

Combining Thyroid Imaging Report and Data System (TIRADS) and Afirma Genomic Sequencing Classifier (GSC) for potential improvement of malignant risk stratification of Bethesda III thyroid nodules

Brian Smola, Xin Jing, Xiaobing Jin, Y. Geng, A. Pandya, W. Hao
article en

Abstract

A GSC-suspicious result combined with TIRADS 5 significantly improved the positive predictive value, thereby enhancing risk stratification in AUS thyroid nodules, while other diagnostic parameters remained unchanged.

Journal of the American Society of Cytopathology
University of Michigan (US), Michigan Medicine (US)
Zero hunger
Openalex Percentile: Top 91%
Thyroid Cancer Diagnosis and Treatment
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