Susceptibility of broad reactivity nanobodies to resistance mutations in the S2 domain of SARS-CoV-2 predicted by yeast display deep mutational scanning
Our study shows that resistance mutations in conserved elements of the S2 domain may still pose a challenge to the development of monoclonal antibodies and subunit vaccines.
Authors
- Walter Ramage
- Simon E. Hufton (ORCID: https://orcid.org/0000-0003-1756-0306)
- Ryan Mate
- Christina Ball
Institutions
- University of Hertfordshire (GB)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-12
- DOI
- https://doi.org/10.3389/fimmu.2025.1726449
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute for Health and Care Research