P-949. Discharge Delays and Costs Associated with Outpatient Parenteral Antimicrobial Therapy for Multi-drug-resistant Organisms: Opportunities for Improvement

Abstract Background The coordination of outpatient parenteral antimicrobial therapy (OPAT) transitions of care is challenging in patients with multi-drug-resistant organisms (MDRO) due to complexity of care. The study purpose was to describe barriers and medication costs associated with OPAT utilizing novel therapies for MDRO.Table 1.Variables associated with receiving a modified outpatient parenteral antimicrobial therapy regimen.Abbreviations: OPAT, outpatient parenteral antimicrobial therapyHosmer-Lemeshow Goodness of Fit testing: Chi-square, 0.030, P=0.985 Methods IRB approved, retrospective cohort of hospitalized adults infected with MDRO that were medically stable for discharge (MSDC) with an intended OPAT for cefiderocol, ceftazidime/avibactam, ceftolozane/tazobactam, eravacycline, meropenem/vaborbactam, or tigecycline from 01/01/2017-03/31/2025. Cohorts included patients who received an intended OPAT regimen or a modified OPAT regimen, defined as transition to alternative intravenous (IV)/oral therapy, in-hospital completion of IV therapy, or in-hospital death. Secondary outcomes included post-MSDC medication costs, excess hospitalization, and opportunities for oral-switch therapy. Results 120 patients were included. 29% had a modified OPAT regimen; 46% completed therapy inpatient and 23% were transitioned to oral therapy. Of the total population, the majority were men (58%) and had Medicare (53%). Intra-abdominal infections were common (38%), and most organisms were carbapenem-resistant (89%). β-lactams were the most intended OPAT regimen (67%). Patients with a modified OPAT regimen had significantly higher medication costs ($4828 [$1209-$18066] vs $1975 [$494-$4872], P< 0.001), more frequently experienced discharge delays ≥ 1 day (89% vs 66%, P=0.011) and prolonged length of stay (LOS) (20 [14-46] vs 13 [7-27], P=0.023), and more commonly required a change in discharge referral disposition (40% vs 16%, P=0.006) when compared to those who received an intended OPAT regimen. An oral-switch therapy opportunity was identified in 40% of patients. After adjusting for Medicaid, referral disposition changes and β-lactam therapy were associated with an increased odds of receiving a modified OPAT regimen (Table 1). Conclusion Modified OPAT regimens were common and associated with increased costs, prolonged LOS, and discharge delays in patients with MRDO infections. Findings support use of oral-switch therapy and improved care coordination. Disclosures All Authors: No reported disclosures