Utility and clinical effectiveness of liquid biopsy-based DNA methylation testing in early tumor screening and diagnosis, emphasizing older adult populations: a systematic review and meta-analysis
CDO1 promoter methylation detection in liquid biopsies shows robust diagnostic accuracy for lung cancer, with performance characteristics supporting its potential clinical utility, particularly for older populations who face barriers to conventional screening. The consistency across diverse specimen types and populations underscores its promise as a minimally invasive screening tool.
Authors
- J. Li
- Desheng Zhu (ORCID: https://orcid.org/0000-0003-0612-0268)
- Haoyu Xu (ORCID: https://orcid.org/0009-0004-1535-6461)
- Yujuan Gao
- Minli Li
Institutions
- Jinhua Academy of Agricultural Sciences (CN)
- Guang Fu Hospital (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Taian City Central Hospital (CN)
- Jinhua Central Hospital (CN)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-01-12
- DOI
- https://doi.org/10.3389/fonc.2025.1739963
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jinhua Science and Technology Bureau