Editorial: Dietary management in kidney diseases: strategies and considerations

The aim of this Research Topic was to explore the multifaceted role of dietary management in kidney diseases, including CKD and glomerulopathies. It intended to evaluate how dietary strategies can be optimized in order to: (1) prevent complications such as volume overload, electrolyte disorders (including hyperphosphatemia and hyperkalemia), acid-base disorders (mainly metabolic acidosis), anemia, and bone and mineral disorders; (2) support overall nutritional health (including the avoidance of protein and calorie malnutrition and of sarcopenia); (3) slow down disease advancement, which may be promoted by diet-related factors including high blood pressure, anemia, urinary protein loss.Diet is known to be implicated in the etiology of CKD, at least as a key determinant in the cardiovascular kidney metabolic syndrome, being crucially involved in the pathophysiological chain leading to obesity, insulin resistance, type 2 diabetes mellitus, cardiovascular disease, diabetic nephropathy and CKD (Ferdinand, 2024). The role of diet as a whole in CKD was explored by the article "Burden and inequalities of chronic kidney disease attributable to diet globally, regionally and temporally, 1990 to 2021" published in this Research Topic. The researchers were able to corroborate the concept that a significant proportion of CKD burden can be diet-related and that this relationship varies across the different regions of the world, concerning trends being noticeable in both low-income as high-income countries. A deficiency in fruits and vegetables is one of the main diet-related factors compounding CKD burden.Protein restrictions are one of the most controversial issues in the dietary management of patients with CKD (Piccoli et al., 2023). One of the articles ("Differential Effects of Plant Protein Ratio on Renal Function and Mortality Across CKD Stages") in this Research Topic addressed this issue, particularly the relevance of the plant protein ratio for the outcome of patients with CKD. The authors reached the conclusion that the dietary recommendations regarding the proportion of plant-derived proteins [classified as low (< 33%), medium (33%-66%), and high (≥ 66%)] should be tailored according to the CKD stage: a medium plant protein intake seemed to be adequate in the early stages of CKD as it correlated with lower mortality as compared with low plant protein diet; however, in the more advanced stages of CKD the benefits of plantderived proteins are less clear.Volume overload and high blood pressure are important complications of CKD and both seem to be related to salt intake, which is another controversial issue in the dietary management of CKD patients (McMahon et al., 2021). The article ("The burden of chronic kidney disease attributable to high sodium intake: a longitudinal study in 1990-2019 in China") in this Research Topic addressing this issue demonstrated that a high sodium intake is an important contributor to the mortality and disability of CKD patients, although there are gender-related and geographic variations.Metabolic acidosis is another complication that may influence the well-being and outcome in patients with CKD and needs to be addressed especially in patients with advanced stages of CKD, one of the strategies consisting in appropriate dietary interventions (Kuhn et al., 2024). This is the subject of another article of this Research Topic ("Correlation between dietary acid-base load and chronic kidney disease patients with type 2 diabetes mellitus"). The researchers enrolled 300 CKD patients in a cross-sectional study and divided them into three groups according to dietary acid load (DAL) tertiles. by means of multivariable logistic regression models, the authors found an association between diet-based acid load scores and the combination of CKD and T2DM -this combination was significantly more prevalent in the highest tertile of DAL as compared to the lowest tertile.The role of diet in more particular kidney disorders was also approached in this Research Topic, one of the articles dealing with the most prevalent among the glomerulopathies: IgA nephropathy ("Effect of time-weighted average 25(OH)D on the occurrence of major adverse kidney events in IgA nephropathy (IgAN): from a 10-year population-based cohort study"). In a study in which 866 patients with IgAN were recruited and followed for a median of 4.3 years, the researchers demonstrated that vitamin D (VD) supplementation is important in IgAN as it reduces the incidence of major adverse kidney events, hence the conclusion that progressive decline in kidney function is slowed down if optimal levels of VD are maintained on the long term. The reason for this beneficial effect are probably the immune-mediating and inflammation-mitigating effects of VD; in particular, in IgAN VD seems to be involved in modulation of OF NFKB1 and NR4A1 expression in proximal tubular cells.The role of particular dietary items was also addressed in this Research Topic, namely the general and kidney health promoting actions of parsley ("Renal Health Benefits and Therapeutic Effects of Parsley (Petroselinum crispum): A Review"). By systematically reviewing scientific databases, the authors gathered information about the effects of parsley, including diuretic (due to inhibition of the Na+/K + -ATPase and to salt and water excretion promoted by myristicin and apiol), antioxidant (attributed to flavonoids and polyphenols), anti-inflammatory (due to flavonoids and essential oil), antidiabetic (assigned to flavonoids such as apigenin), antimicrobial (attributed to the monoterpenes in the essential oil and to furocoumarins), and many others. The nephroprotective action of parsley appears to be a corollary of the diuretic, antioxidant, and anti-inflammatory effects of parsley. Most evidence consisted of the results of animal studies; only a few small powered human studies were available indicating renal health benefits particularly in obese females.A very popular topic nowadays is the gut microbiome which seems to be involved in all types of pathological processes, including metabolic syndrome (Wu et al., 2021), and thereby in cardiovascular kidney metabolic syndrome, a topic tackled by another article ("Gut microbiotaderived SCFAs and MetS-related nephropathy") in this Research Topic. The authors of this article point out that, besides the anti-inflammatory, antioxidant, and lipid improvement effects, gut microbiota also produces short-chain fatty acids (SCFAs) which serve as a source of energy for the human cells, modulate immune and inflammatory processes, fend off oxidative stress, prevent mitochondrial damage, thereby mitigating all the processes responsible for the kidney injury associated with metabolic syndrome.Hence this Research Topic provides a broad overview of the role of dietary interventions in slowing down the pace of kidney deterioration and ameliorating chronic kidney disease, in preventing its complications (such as metabolic acidosis and protein malnutrition), by both modulating the various pathophysiological processes involved in its progression (particularly inflammation, oxidative stress, immune dysregulation, gut dysbiosis) and preventing/ ameliorating systemic disorders involved in the pathogenesis of CKD (especially the metabolic ones: diabetes, obesity, metabolic syndrome).