Design and Synthesis of Novel Dihydronaphthalene-Based Triazole Scaffolds as Potential Antimicrobial Agents

Due to the emergence of drug-resistant bacterial and fungal infection researchers worldwide are trying to discover the new generations of antibiotics. In this study, the antibacterial and antifungal potential of library of dihydronaphthalene based-triazole scaffolds were synthesized and evaluated against the various gram-positive (S. pneumoniae and M. luteus), gram-negative (E. coli, H. influenzae, K. pneumonia and N. mucosa) bacteria strains and fungal (C. glabrata, C. parapsilosis, and C. albicans) strains. Among all the synthesized compounds four derivatives exhibited strong activity against the various pathogens like K. pneumoniae, S. pneumoniae, M. luteus, C. glabrata, C. albicans etc.