Case Report: Prolonged DAWS in an RLS patient under severe relational stress

This case illustrates that DAWS can occur in RLS patients even at low DA doses, with atypical symptoms possibly involving autonomic and central sensitization. Relational stress may significantly exacerbate symptom severity, potentially leading to profound neurological destabilization through mechanisms such as cross-system hypersensitivity or a kindling-like process, as suggested by existing literature. This factor may need to be systematically assessed in DAWS management. As a rare patient-authored account, this report contributes to the understanding of DAWS in non-PD populations and highlights the need for longitudinal research to guide safer withdrawal protocols and integrated care.

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Publication Details

Journal
Frontiers in Human Neuroscience
Published
2026-01-12
DOI
https://doi.org/10.3389/fnhum.2025.1613710
Primary Topic
Restless Legs Syndrome Research
Type
article
Field-Weighted Citation Impact
0.00

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Case Report: Prolonged DAWS in an RLS patient under severe relational stress

M. Gillon
Frontiers in Human Neuroscience
Restless Legs Syndrome Research
article

Case Report: Prolonged DAWS in an RLS patient under severe relational stress

M. Gillon
article en

Abstract

This case illustrates that DAWS can occur in RLS patients even at low DA doses, with atypical symptoms possibly involving autonomic and central sensitization. Relational stress may significantly exacerbate symptom severity, potentially leading to profound neurological destabilization through mechanisms such as cross-system hypersensitivity or a kindling-like process, as suggested by existing literature. This factor may need to be systematically assessed in DAWS management. As a rare patient-authored account, this report contributes to the understanding of DAWS in non-PD populations and highlights the need for longitudinal research to guide safer withdrawal protocols and integrated care.

Frontiers in Human NeuroscienceVol. 19
University of Liège (BE)
Fonds De La Recherche Scientifique - FNRS
Good health and well-being
Openalex Percentile: Top 91%
Restless Legs Syndrome Research
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