α-Klotho Promotes Cell Death and Suppresses Inflammation through TNF-Cellular Inhibitor of Apoptosis Protein 1 Signaling in Autosomal Dominant Polycystic Kidney Disease
This study defined an unknown role and mechanism of α Klotho in the regulation of a TNF-dependent cystic cell apoptosis and inflammation in Pkd1 mutant kidneys.
Authors
- Xiaoyan Li (ORCID: https://orcid.org/0000-0002-7460-0776)
- Xiaogang Li
- C. I. Huang
- Hongbing Zhang
- James P. Calvet
- Julie X. Zhou
Institutions
- University of Iowa (US)
- Mayo Clinic (US)
- University of Kansas Medical Center (US)
Publication Details
- Journal
- Journal of the American Society of Nephrology
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1681/asn.0000000940
- Primary Topic
- Genetic and Kidney Cyst Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00