Multi-center evaluation of radiomics and deep learning to stratify malignancy risk of IPMNs
The fusion model, which combines DL with radiomics features from routine T2W MRI, shows promise for objective, cyst-level risk stratification of IPMNs in a multi-center cohort, outperforming radiomics-only models and nearly matching expert radiologists using only T2W and T1-weighted (T1W) sequences. While performance requires improvement for standalone clinical use, this approach offers a scalable, non-invasive method to potentially improve diagnostic accuracy and reduce unnecessary surgical interventions.
Authors
- Emil Agarunov
- Ivo G. Schoots (ORCID: https://orcid.org/0000-0002-9804-0603)
- Pallavi Tiwari (ORCID: https://orcid.org/0009-0004-3050-8531)
- A Medetalibeyoglu
- Candice W. Bolan (ORCID: https://orcid.org/0000-0002-9847-3599)
- Andrea Bejar (ORCID: https://orcid.org/0000-0003-2089-5983)
- Görkem DURAK (ORCID: https://orcid.org/0000-0002-8375-876X)
- Chao Chen (ORCID: https://orcid.org/0000-0003-1703-6483)
- Zheyuan Zhang (ORCID: https://orcid.org/0000-0001-9516-4603)
- MJ Bruno
- Bagci Ulas
- Ziliang Hong
- Ziyue Xu
- Halil Ertugrul Aktas
- Gulbiz Dagoglu Kartal
- Fergan Bol
- Lili Zhao
- Elif Keles
- Sachin Jambawalikar
- Hongyi Pan
- Michael B Wallace
- Rajesh N Keswani
- Tamas Gonda
- Zeynep Sue Jozwiak
- Sukru Mehmet Erturk
- Frank H Miller
- Chenchang Huang
- Yury Velichko
- Maria Jaramillo Gonzalez
Institutions
- Northwestern University (US)
- University of Wisconsin–Madison (US)
- Stony Brook University Hospital (US)
- Jacksonville College (US)
- Erasmus MC (NL)
- WinnMed (US)
- University of Catania (IT)
- Bakırköy Dr.Sadi Konuk Eğitim ve Araştırma Hastanesi (TR)
- Nvidia (United States) (US)
- William S. Middleton Memorial Veterans Hospital (US)
- Mayo Clinic in Florida (US)
- Northwestern Medicine (US)
- New York University (US)
- Istanbul University (TR)
- Columbia University (US)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Abdominal Radiology
- Published
- 2026-01-12
- DOI
- https://doi.org/10.1007/s00261-025-05371-3
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wisconsin Alumni Research Foundation
- National Institutes of Health