Clinical validation and utility of targeted nanopore sequencing for rapid pathogen diagnosis and precision therapy in lung cancer patients with pulmonary infections
By enabling rapid pathogen detection and profiling of the pulmonary microbiome, TNPseq facilitates targeted therapy and reduces antibiotic overuse in LC patients. These findings highlight the potential of TNPseq as a promising, rapid, and non-invasive diagnostic candidate for first-line use, offering a comprehensive view of both infection and host-microbe interactions in immunocompromised patients.
Authors
- Yunfei Wang (ORCID: https://orcid.org/0000-0003-1371-278X)
- Qin Deng (ORCID: https://orcid.org/0000-0002-0841-6575)
- Min Jia (ORCID: https://orcid.org/0009-0006-3064-9953)
- Wei Wang (ORCID: https://orcid.org/0000-0002-3143-0623)
- Yanzhe Liu (ORCID: https://orcid.org/0009-0002-7629-1265)
- Yiyong Zhang
- Jian Zhang
- Dushan Ding
- Hongcang Gu
- Yuqin Fang
- Hongshan Zhang
- Meng Wang
Institutions
- University of Science and Technology of China (CN)
- Hefei Institutes of Physical Science (CN)
- Hefei University (CN)
- Hangzhou Center for Disease Control and Prevention (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-01-12
- DOI
- https://doi.org/10.3389/fcimb.2025.1730098
- Primary Topic
- Genomics and Phylogenetic Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00