Associations of lifetime cumulative estrogen exposure with lifecourse social exposures, cognitive decline, and dementia risk among postmenopausal White, Black, and Latina women

Cumulative estrogen exposure is socially patterned. We found that lifecourse social factors and estrogen exposure synergistically contribute to women's late-life cognitive health outcomes. Understanding how sex-linked biology and gender-related social forces intertwine is essential for developing interventions to decrease dementia risk among women.

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Publication Details

Journal
The Journals of Gerontology Series B
Published
2026-01-07
DOI
https://doi.org/10.1093/geronb/gbag001
Primary Topic
Menopause: Health Impacts and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Associations of lifetime cumulative estrogen exposure with lifecourse social exposures, cognitive decline, and dementia risk among postmenopausal White, Black, and Latina women

Mateo Farina, Justina F. Avila-Rieger, Nicole Schupf, Sarah Tom et al.
The Journals of Gerontology Series B
Menopause: Health Impacts and Treatments
article

Associations of lifetime cumulative estrogen exposure with lifecourse social exposures, cognitive decline, and dementia risk among postmenopausal White, Black, and Latina women

Mateo Farina, Justina F. Avila-Rieger, Nicole Schupf, Sarah Tom, Adam M Brickman, Richard P Mayeux, Benjamin Huber, Whitney R Robinson, Tanisha G Hill-Jarrett, Jennifer J Manly
article en

Abstract

Cumulative estrogen exposure is socially patterned. We found that lifecourse social factors and estrogen exposure synergistically contribute to women's late-life cognitive health outcomes. Understanding how sex-linked biology and gender-related social forces intertwine is essential for developing interventions to decrease dementia risk among women.

The Journals of Gerontology Series BVol. 81(3)
Duke University (US), Trinity College (CA), Trinity College Dublin (IE), University Memory and Aging Center (US), Global Brain Health Institute (US), Columbia University (US), The University of Texas at Austin (US), Vanderbilt University Medical Center (US)
Gender equality
Openalex Percentile: Top 91%
Menopause: Health Impacts and Treatments
DOIOpen Access PDFOpenAlex
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