Isavuconazole in the treatment of acute invasive fungal sinusitis: two case reports and literature review
In the described cases, ours patients received isavuconazole pre- and post-surgery, achieving favorable prognostic outcomes. Literature comparisons further validate these findings, demonstrating that the efficacy of the new triazole drug isavuconazole in treating invasive aspergillosis and mucormycosis significantly surpasses that of amphotericin B, with efficacy comparable to voriconazole (<i>p</i> < 0.05). These results provide valuable guidance for clinical medication decisions.
Authors
- L. Wang
- He Zhao (ORCID: https://orcid.org/0000-0001-5095-1777)
- Fengbo Yang
- Huhuifen He
- Kun Zhao (ORCID: https://orcid.org/0000-0001-9871-4957)
- Yuwan Song
- Yan Sun
- Yan Wang
Institutions
- Binzhou Medical University (CN)
- Shandong University of Aeronautics (CN)
- Yuhuangding Hospital (CN)
- Humboldt-Universität zu Berlin (DE)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-01-12
- DOI
- https://doi.org/10.3389/fmed.2025.1700685
- Citations
- 1
- Primary Topic
- Sinusitis and nasal conditions
- Type
- article
- Field-Weighted Citation Impact
- 53.14
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province