Efficacy of Inhalable Endolysin Cpl-1 Formulations in Combination with Gentamicin or Endolysin Pal in a Murine Lung Infection Model
This proof-of-principle study demonstrated that inhalable endolysin liquid and powder formulations could potentially be used to treat bacterial lung infections. Moreover, the combination of multiple endolysins could increase antimicrobial activity over endolysin monotherapy.
Authors
- Trixie Wang
- Adit B. Alreja (ORCID: https://orcid.org/0000-0003-3607-8005)
- Warwick J. Britton (ORCID: https://orcid.org/0000-0001-6721-9646)
- Maxwell T. Stevens
- Yuncheng Wang
- Daniel C. Nelson
Institutions
- University of Maryland, Baltimore (US)
- The University of Sydney (AU)
- National Institute of Standards and Technology (US)
- Royal Prince Alfred Hospital (AU)
- Centenary Institute (AU)
- Institute for Bioscience and Biotechnology Research
- University of Maryland, College Park (US)
Publication Details
- Journal
- Pharmaceutical Research
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1007/s11095-025-03942-z
- Primary Topic
- Inhalation and Respiratory Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- Medical Research Council
- National Health and Medical Research Council