Low IgE and absence of sensitization in non-T2 asthma: a transcriptomic and cytokine study

Non-type 2 asthma represents a distinct inflammatory endotype characterized by impaired type 2 helper cell differentiation, inhibited B-cell activation and immunoglobulin E class switching, and possibly skewed immunoglobulin variable gene usage linked to altered antibody specificity. These findings suggest a multi-faceted mechanism involving broad inhibition of key sensitization and immunoglobulin E production pathways, explaining the low serum immunoglobulin E levels and the absence of allergic sensitization in non-type 2 asthma.