The Mutation Patterns of <i>MET</i> Gene in Lung Cancer and Brain Tumors: Clinical and Therapeutic Implications

Our study demonstrated that the biological and clinical significance of MET alterations is highly context dependent. In lung cancer, MET serves primarily as a predictive biomarker for targeted therapy, whereas in brain tumors, it functions as a prognostic marker of genomic instability and aggressive disease. These findings advocate for context-specific clinical management strategies.

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Publication Details

Journal
Cancer Medicine
Published
2026-01-01
DOI
https://doi.org/10.1002/cam4.71532
Primary Topic
Lung Cancer Treatments and Mutations
Type
article
Field-Weighted Citation Impact
0.00

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article

The Mutation Patterns of MET Gene in Lung Cancer and Brain Tumors: Clinical and Therapeutic Implications

D. Chen, Yongmeng Li, Ningning Luo, Minghui Ge et al.
Cancer Medicine
Lung Cancer Treatments and Mutations
article

The Mutation Patterns of MET Gene in Lung Cancer and Brain Tumors: Clinical and Therapeutic Implications

D. Chen, Yongmeng Li, Ningning Luo, Minghui Ge, Yanxiang Zhang, Yu Zhang
article en

Abstract

Our study demonstrated that the biological and clinical significance of MET alterations is highly context dependent. In lung cancer, MET serves primarily as a predictive biomarker for targeted therapy, whereas in brain tumors, it functions as a prognostic marker of genomic instability and aggressive disease. These findings advocate for context-specific clinical management strategies.

Cancer MedicineVol. 15(1)
Hebei Medical University (CN), Simcere Pharmaceutical (China) (CN), Shandong Provincial QianFoShan Hospital (CN), First Affiliated Hospital of Hebei Medical University (CN), Shandong First Medical University (CN)
Natural Science Foundation of Shandong Province
Openalex Percentile: Top 91%
Lung Cancer Treatments and Mutations
DOIOpen Access PDFOpenAlex
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The Mutation Patterns of <i>MET</i> Gene in Lung Cancer and Brain Tumors: Clinical and Therapeutic Implications — D. Chen, Yongmeng Li, et al. · Cancer Medicine (2026) | TGRS Research Map | TGRS