Unmasking malignancy—thyrotoxic hypokalemic periodic paralysis and papillary thyroid carcinoma in a young male with Graves’ disease: a case report

This case illustrates the rare triad of THPP, Graves' disease, and PTC. In this patient, an episode of THPP served as the clinical trigger that led to further thyroid evaluation and ultimately the diagnosis of an aggressive and multifocal thyroid malignancy. It emphasizes the need for thorough thyroid evaluation in patients with Graves' disease who present with THPP, as an underlying malignancy may be present. Early imaging, cytologic assessment, and surgical consultation should be considered.

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Publication Details

Journal
AME Case Reports
Published
2026-01-01
DOI
https://doi.org/10.21037/acr-2025-212
Primary Topic
Thyroid Disorders and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Unmasking malignancy—thyrotoxic hypokalemic periodic paralysis and papillary thyroid carcinoma in a young male with Graves’ disease: a case report

Michael Bouvet, Grace Lin, Ting-Chun Kuo, Julian W. Fricks et al.
AME Case Reports
Thyroid Disorders and Treatments
article

Unmasking malignancy—thyrotoxic hypokalemic periodic paralysis and papillary thyroid carcinoma in a young male with Graves’ disease: a case report

Michael Bouvet, Grace Lin, Ting-Chun Kuo, Julian W. Fricks, Julie Bykowski
article en

Abstract

This case illustrates the rare triad of THPP, Graves' disease, and PTC. In this patient, an episode of THPP served as the clinical trigger that led to further thyroid evaluation and ultimately the diagnosis of an aggressive and multifocal thyroid malignancy. It emphasizes the need for thorough thyroid evaluation in patients with Graves' disease who present with THPP, as an underlying malignancy may be present. Early imaging, cytologic assessment, and surgical consultation should be considered.

AME Case ReportsVol. 10
University of California San Diego (US), National Taiwan University Hospital (TW), University of California San Diego Medical Center (US)
Good health and well-being
Openalex Percentile: Top 91%
Thyroid Disorders and Treatments
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Unmasking malignancy—thyrotoxic hypokalemic periodic paralysis and papillary thyroid carcinoma in a young male with Graves’ disease: a case report — Michael Bouvet, Grace Lin, et al. · AME Case Reports (2026) | TGRS Research Map | TGRS