Unmasking malignancy—thyrotoxic hypokalemic periodic paralysis and papillary thyroid carcinoma in a young male with Graves’ disease: a case report
This case illustrates the rare triad of THPP, Graves' disease, and PTC. In this patient, an episode of THPP served as the clinical trigger that led to further thyroid evaluation and ultimately the diagnosis of an aggressive and multifocal thyroid malignancy. It emphasizes the need for thorough thyroid evaluation in patients with Graves' disease who present with THPP, as an underlying malignancy may be present. Early imaging, cytologic assessment, and surgical consultation should be considered.
Authors
- Michael Bouvet (ORCID: https://orcid.org/0000-0002-0086-2159)
- Grace Lin (ORCID: https://orcid.org/0000-0001-8018-5604)
- Ting-Chun Kuo
- Julian W. Fricks
- Julie Bykowski
Institutions
- University of California San Diego (US)
- National Taiwan University Hospital (TW)
- University of California San Diego Medical Center (US)
Publication Details
- Journal
- AME Case Reports
- Published
- 2026-01-01
- DOI
- https://doi.org/10.21037/acr-2025-212
- Primary Topic
- Thyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00