Tuberculosis‐Associated Paradoxical Immune Reconstitution Inflammatory Syndrome in an <scp>HIV</scp> ‐Negative Patient Presenting With a Recurrent Pleural Effusion Managed With Prednisolone: A Case Report

Non-HIV-infected people with pulmonary tuberculosis can develop paradoxical worsening of lung conditions, including massive pleural effusion, which at times requires multiple drainage. This paradoxical immune reconstitution inflammatory syndrome can successfully be treated with a short course of steroids, resulting in symptom, quality of life, and imaging improvements.

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Publication Details

Journal
Clinical Case Reports
Published
2026-01-01
DOI
https://doi.org/10.1002/ccr3.71843
Primary Topic
Infectious Diseases and Tuberculosis
Type
article
Field-Weighted Citation Impact
0.00
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article

Tuberculosis‐Associated Paradoxical Immune Reconstitution Inflammatory Syndrome in an HIV ‐Negative Patient Presenting With a Recurrent Pleural Effusion Managed With Prednisolone: A Case Report

Selam Bogale Gissa, Alemayehu Girma Gemechu, Selamawit Tilahun
Clinical Case Reports
Infectious Diseases and Tuberculosis
article

Tuberculosis‐Associated Paradoxical Immune Reconstitution Inflammatory Syndrome in an HIV ‐Negative Patient Presenting With a Recurrent Pleural Effusion Managed With Prednisolone: A Case Report

Selam Bogale Gissa, Alemayehu Girma Gemechu, Selamawit Tilahun
article en

Abstract

Non-HIV-infected people with pulmonary tuberculosis can develop paradoxical worsening of lung conditions, including massive pleural effusion, which at times requires multiple drainage. This paradoxical immune reconstitution inflammatory syndrome can successfully be treated with a short course of steroids, resulting in symptom, quality of life, and imaging improvements.

Clinical Case ReportsVol. 14(1)
St. Paul's Hospital Millennium Medical College (ET), Addis Ababa University (ET)
Openalex Percentile: Top 91%
Infectious Diseases and Tuberculosis
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Tuberculosis‐Associated Paradoxical Immune Reconstitution Inflammatory Syndrome in an <scp>HIV</scp> ‐Negative Patient Presenting With a Recurrent Pleural Effusion Managed With Prednisolone: A Case Report — Selam Bogale Gissa, Alemayehu Girma Gemechu, et al. · Clinical Case Reports (2026) | TGRS Research Map | TGRS