Fully human anti-B7-H4 antibody induces lysosome-dependent ferroptosis to reverse primary resistance to PD-1 blockade
Our study identifies a novel mechanism by which a fully human anti-B7-H4 antibody induces lysosome-dependent immunogenic tumor cell death. These findings support the therapeutic potential of A8 as a single agent or in combination with PD-1 blockade to overcome immune resistance in B7-H4-expressing "cold" tumors.
Authors
- B. Zheng
- Yunhan Chen (ORCID: https://orcid.org/0000-0002-6891-6715)
- Qiumei Cao
- Zhengyun Cao
- Yanyang Zhu
- Yang Wang
- Renlu Zhang
- Linlin Zhou
- Qiuyu Zhang
- Yue Wu
Institutions
- Fujian Medical University (CN)
- Collaborative Group (United States) (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1136/jitc-2025-013317
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 36.44