P-75. Comparison of clinical characteristics and Outcome of Brucella Vertebral Osteomyelitis and Pyogenic Vertebral Osteomyelitis: A 5 year retrospective Study

Abstract Background Vertebral osteomyelitis (VO) is a serious infection with varying clinical courses depending on the underlying etiology. This study compares the clinical profile, radiological features, and outcomes of Brucella vertebral osteomyelitis (BVO) and Pyogenic vertebral osteomyelitis (PVO). Outcome and subgroup anlysis Methods A comparative study was conducted involving 328 patients—164 with BVO were compared with 164 with PVO, randomized and matched based on age, gender and presence of diabetes. Demographics, vertebral involvement, clinical presentation, treatment modalities, and outcomes were evaluated. Functional recovery was assessed using EQ-5D scores at 1 and 2 years. Conclusion BVO patients had an earlier onset, requiring lesser surgical intervention fewer neurological complications and had lesser requirement of surgical intervention. BVO had better functional outcomes and higher EQ-5D scores at 1 and 2 years compared to PVO. This study highlights the prognostic implications of underlying aetiology in vertebral osteomyelitis. Disclosures All Authors: No reported disclosures