Association of Time to Antibiotics With Outcome in Pediatric Patients Receiving Chemotherapy for Cancer With Fever in Neutropenia—An International Individual Patient Data Meta‐Analysis
This large, international and adequately powered IPD meta-analysis found no association between shorter TTA and improved clinical outcomes in pediatric patients with FN. This finding was consistent across analyses. These results challenge the continued use of TTA limits as a quality measure for pediatric oncology centers.
Authors
- Konrad Bochennek (ORCID: https://orcid.org/0000-0002-6881-6511)
- Lee J. Berriault Sandy Dupuis
- Eva Brack (ORCID: https://orcid.org/0000-0001-5799-3187)
- Caitlin W. Elgarten (ORCID: https://orcid.org/0000-0002-2474-3031)
- Gabrielle M. Haeusler (ORCID: https://orcid.org/0000-0003-0371-8176)
- Adam J. Esbenshade (ORCID: https://orcid.org/0000-0002-0154-4996)
- Christa Koenig (ORCID: https://orcid.org/0000-0002-9965-5183)
- Nadja Hawwa Vissing (ORCID: https://orcid.org/0000-0003-0662-2727)
- Mia Karamatsu
- Bob Phillips
- Lillian Sung
- Amelie L. Salomon
- Emily Schaeffer
- Roland A. Ammann
- Mette B. Moenster
Institutions
- Goethe University Frankfurt (DE)
- University of Bern (CH)
- Royal Children's Hospital (AU)
- Children's Hospital of Philadelphia (US)
- Palo Alto University (US)
- Leeds Teaching Hospitals NHS Trust (GB)
- Peter MacCallum Cancer Centre (AU)
- AHEPA University Hospital (GR)
- University Hospital of Bern (CH)
- Hospital for Sick Children (CA)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- Monroe Carell Jr. Children's Hospital (US)
- Ammann (Switzerland) (CH)
- University of York (GB)
- Stanford University (US)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1002/cam4.71512
- Primary Topic
- Neutropenia and Cancer Infections
- Type
- article
- Field-Weighted Citation Impact
- 0.00