Atypical Depression Is Associated With a Distinct Clinical, Neurobiological, Treatment Response, and Polygenic Risk Profile
This large, genetically informative study supports the neurobiological and clinical validity of atypical depression, demonstrating distinct clinical and genetic risk profiles alongside differential antidepressant responses. These findings support the use of the atypical subtype to guide treatment selection and physical health management.
Authors
- Jackson G. Thorp (ORCID: https://orcid.org/0000-0002-9461-6417)
- Mirim Shin (ORCID: https://orcid.org/0000-0002-1648-341X)
- Kathleen R. Merikangas (ORCID: https://orcid.org/0000-0002-4667-2414)
- Emiliana Tonini (ORCID: https://orcid.org/0000-0002-8582-0491)
- Joanne Sarah Carpenter (ORCID: https://orcid.org/0000-0002-9766-6700)
- Ian Bernard Hickie (ORCID: https://orcid.org/0000-0001-8832-9895)
- Lin Tian
- Naomi R. Wray
- Jacob J. Crouse
- Nicholas G. Martin
- Sarah Mckenna
- Sarah E. Medland
- Richard Parker
- Penelope A. Lind
Institutions
- The University of Sydney (AU)
- The University of Queensland (AU)
- QIMR Berghofer Medical Research Institute (AU)
- University of Oxford (GB)
- National Institute of Mental Health (US)
Publication Details
- Journal
- Biological Psychiatry
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1016/j.biopsych.2026.01.003
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 0.00