Distinct subcortical neuroanatomic profiles of treatment-resistant schizophrenia: structural magnetic resonance imaging study
These results suggest that smaller hippocampal and amygdala volumes represent a shared neuroanatomical signature of schizophrenia, whereas reduced accumbens and enlarged pallidal volumes may differentiate treatment-resistant and treatment-responsive profiles, respectively. The findings underscore the heterogeneity of schizophrenia and highlight the need for longitudinal research to disentangle illness-related pathology from medication effects.
Authors
- Kaan Keskin (ORCID: https://orcid.org/0000-0003-2116-3952)
- Ömer Kitiş (ORCID: https://orcid.org/0000-0003-4201-5449)
- Yiğit Erdoğan
- Asli Ceren Hinc
- Ibrahim Sungur (ORCID: https://orcid.org/0009-0005-1043-2100)
- Elif Özge Aktaş (ORCID: https://orcid.org/0000-0002-0505-1662)
- Furkan Yazici
- Ali Saffet Gonul
- Simay Selek
Institutions
- Mercer University Health Sciences Center (US)
- Ege University (TR)
Publication Details
- Journal
- BJPsych Open
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1192/bjo.2025.10939
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ege Üniversitesi