Renal function decline after radical nephroureterectomy: Longitudinal analysis and predictive factors in upper tract urothelial carcinoma

RNU significantly and adversely affects postoperative renal function in patients with UTUC. Preoperative eGFR and tumor size are the most influential predictors of postoperative renal function. The identified predictors may assist clinicians in anticipating postoperative renal outcomes, thereby informing surgical decision-making and preoperative counseling aimed at balancing oncological control and renal preservation.