Gray matter volume and functional connectivity identify asymptomatic MAPT variant carriers with signs of longitudinal disease progression
Lower baseline GMV within regions atrophied during the symptomatic phase and longitudinal FC declines within MAPT-relevant networks may signal earlier symptomatic conversion in Asymp-MAPT.
Authors
- Liwen Zhang (ORCID: https://orcid.org/0000-0002-8533-9075)
- Virginia E. Sturm (ORCID: https://orcid.org/0000-0002-1717-298X)
- Taru Flagan (ORCID: https://orcid.org/0009-0003-6566-9696)
- Maria Luisa Gorno Tempini
- Brad F Boeve
- Youjin Jung
- Maria Luisa Mandelli
- Leah K. Forsberg
- ARTFL/LEFFTDS/ALLFTD Consortia
- Eliana Marisa Ramos
- Adam L. Boxer
- William W. Seeley
- Kejal Kantarci
- Bruce L. Miller
- Hilary W. Heuer
- Suzee E. Lee
- Howard J. Rosen
- Jennifer S. Yokoyama
Institutions
- University of California, Los Angeles (US)
- University of California, San Francisco (US)
- Shanghai Jiao Tong University (CN)
- Ruijin Hospital (CN)
- University Memory and Aging Center (US)
- Mayo Clinic in Arizona (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_105877
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00