Plasma proteome‐wide analysis of dementia risk mechanistically implicates synaptic biomarkers
These results suggest that synaptic proteins are released from the CNS into the blood well before symptom onset. Synaptic proteins measured in blood, such as CPLX1, may represent mechanistically relevant biomarkers of AD dementia risk.
Authors
- Joni V. Lindbohm (ORCID: https://orcid.org/0000-0002-9820-2692)
- Gabriela Gómez (ORCID: https://orcid.org/0000-0002-1761-0070)
- Shi Liu (ORCID: https://orcid.org/0000-0002-4916-9312)
- Noel J. Buckley (ORCID: https://orcid.org/0000-0003-1152-0653)
- Alejo Nevado‐Holgado (ORCID: https://orcid.org/0000-0001-9276-2720)
- JINGSHA CHEN
- Linda Zhou (ORCID: https://orcid.org/0000-0002-1156-7315)
- M Kivimaki
- Yunju Yang
- Peter R. Ganz
- Keenan A. Walker
- Zhongsheng Peng
- Christie M Ballantyne
- Aditya Surapaneni
- Morgan E Grams
- Myriam Fornage
- Ron C. Hoogeveen
- Pascal Schlosser
- Thomas H. Mosley
- Josef Coresh
- Eric Boerwinkle
- Kevin J. Sullivan
- Adrienne Tin
- Rebecca F. Gottesman
Institutions
- National Institutes of Health (US)
- Department of Health and Social Care (GB)
- Johns Hopkins University (US)
- Baylor College of Medicine (US)
- Johns Hopkins Medicine (US)
- Jackson Memorial Hospital (US)
- University of Mississippi Medical Center (US)
- University of Oxford (GB)
- University of California San Francisco Medical Center (US)
- National Institute of Neurological Disorders and Stroke (US)
- Brown Foundation (US)
- National Institute on Aging (US)
- Heptares Therapeutics (United Kingdom) (GB)
- Artificial Intelligence in Medicine (Canada) (CA)
- University College London (GB)
- New York University (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_105743
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00