Association of plasma biomarkers for Alzheimer's disease with cognitive change among Hispanic/Latino adults: preliminary findings from HCHS/SOL and SOL‐INCA
Preliminary findings suggest plasma biomarkers for pTau-181, pTau-181/Aβ<sub>42</sub>, NfL, and GFAP predict cognitive decline before symptoms manifest. Individuals with high levels of these biomarkers are at elevated risk for age-related cognitive decline. The threshold for differences in the trajectories varies by biomarker and differences in trajectories are more apparent in older age suggesting the likelihood for nonlinear change.
Authors
- Humberto Parada (ORCID: https://orcid.org/0000-0001-6562-8577)
- Galasko Dr
- Freddie Márquez
- Fernando Daniel Testai (ORCID: https://orcid.org/0000-0002-7355-4915)
- Paola Filigrana (ORCID: https://orcid.org/0000-0002-8297-3943)
- Deisha F. Valencia
- Natasha Z. Anita
- Bharat Thyagarajan
- Hector M Gonzalez
- Linda C Gallo
- Wassim Tarraf
- Carmen R Isasi
- Charles Decarli
- Martha L Daviglus
Institutions
- University of North Carolina at Chapel Hill (US)
- Albert Einstein College of Medicine (US)
- University of Minnesota (US)
- Wayne State University (US)
- San Diego State University (US)
- University of California San Diego (US)
- University of Illinois Chicago (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- University of California, Davis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_105946
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00