APOE Genotype Modulates the Relationship Between Plasma <i>p</i> ‐tau217 and Amyloid Burden in Alzheimer's Disease
This study demonstrates that APOE genotype significantly modulates the relationship between plasma p-tau217 and amyloid burden in Alzheimer's disease. Plasma p-tau217 showed stronger correlations with amyloid burden in individuals with APOE E2 and E3 genotypes compared to those with the E4 genotype, highlighting its potential as a sensitive biomarker for amyloid pathology in non-E4 carriers.
Authors
- Philip B. Verghese (ORCID: https://orcid.org/0000-0003-4793-564X)
- You Jin Kim (ORCID: https://orcid.org/0000-0002-4952-5532)
- Kristopher M. Kirmess (ORCID: https://orcid.org/0000-0002-0306-323X)
- Joel B. Braunstein (ORCID: https://orcid.org/0000-0002-1155-0206)
- Han‐Kyeol Kim (ORCID: https://orcid.org/0000-0002-7650-6708)
- Mina Park (ORCID: https://orcid.org/0000-0003-1217-5644)
- Jae Hoon Lee (ORCID: https://orcid.org/0000-0001-9777-5918)
- Hanna Cho (ORCID: https://orcid.org/0000-0002-5339-2541)
- Tim West
- Young Ryu
- Daniel Connell
- Joong‐Hyun Chun
- Chul Hyoung Lyoo
Institutions
- Yonsei University (KR)
- Severance Hospital (KR)
- C2N Diagnostics (United States) (US)
- Wonju Severance Christian Hospital (KR)
- Gangnam Severance Hospital (KR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_106200
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00