Hippocampal Subfield Volumes, Depression and Cognitive Decline in Alzheimer's Disease: A Longitudinal 7T Study

The study underscores the importance of hippocampal subfield volumes as markers of cognitive decline in AD. While depression correlates with subfield volumes in AD, this relationship is absent in healthy controls, suggesting distinct neurobiological underpinnings. These findings provide insights into potential targets for early intervention and highlight the need for further longitudinal studies.