Reduced Adenosine Triphosphate-to-Phosphocreatine Ratios in Neuropsychiatric Post-COVID Condition: Evidence From 31P Magnetic Resonance Spectroscopy
Our study provides the first in vivo evidence of impaired brain energy metabolism in PCCo, with anterior cingulate dysfunction directly linked to cognitive impairment. The observed pH-ATP/PCr relationship suggests broader disruption of cellular bioenergetic regulation. These findings support mitochondrial dysfunction as a key pathophysiological mechanism and may inform targeted therapeutic strategies.
Authors
- Cláudia Schilling (ORCID: https://orcid.org/0000-0001-7631-1452)
- Robert E. Becker (ORCID: https://orcid.org/0000-0003-4080-4452)
- Wolfgang Weber‐Fahr (ORCID: https://orcid.org/0000-0003-3503-7041)
- Ende Gabriele
- Nabil Alzein
- Markus Sack
- Sandra Dommke
- Traute Demirakca
Institutions
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Central Institute of Mental Health (DE)
Publication Details
- Journal
- Biological Psychiatry
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1016/j.biopsych.2026.01.004
- Citations
- 1
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 39.15